Water Mediated: An Efficient Synthesis of 2-Amino-6-[1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl]-4-(1H-indol-3-yl)-4H-pyran-3,5-dicarbonitriles
摘要
Abstract
A novel series of 2-amino-6-(1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)-4-(1H-indol-3-yl)-4Hpyran-3,5-dicarbonitrile derivatives were produced utilizing water as the reaction medium in a one-pot four-component synthesis with phthalic acid, 2-cyanoacetohydrazide, 1H-indole-3-carbaldehydes, and malononitrile. This one-pot four-component reaction offers the amazing advantages of a simple protocol, low environmental impact, rapid reaction periods, and high yields.