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Abstract <p>The azlactone method was used to synthesize methyl esters of <i>N</i>-substituted α,β-dehydrophenylalanyl, and tyrosyl dipeptides, which were converted by alkaline hydrolysis into the corresponding peptides in good yields (65–93%). From the latter, 4-arylidene-5-oxo-4,5-dihydro-1<i>H</i>-imidazol-1-yl carboxylic acids were obtained using 1,1,1,3,3,3-hexamethyldisilazane as a dehydrating agent. The antiradical and anticholinesterase properties of the synthesized compounds were investigated. UV and fluorescence spectra were studied.</p>

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Synthesis, Antiradical and Anticholinesterase Properties of N-Substituted α,β-Dehydrodipeptides and Corresponding 4-Arylidene-5-oxo-4,5-dihydro-1H-imidazol-1-ylcarboxylic Acids

  • 期刊论文

  • 发表日期：

    2025年6月1日

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  • A. T. Makichyan,
  • A. A. Hovhannisyan,
  • A. A. Shahkhatuni,
  • E. A. Hakobyan,
  • V. O. Topuzyan,
  • L. Kh. Galstyan

摘要

Abstract

The azlactone method was used to synthesize methyl esters of N-substituted α,β-dehydrophenylalanyl, and tyrosyl dipeptides, which were converted by alkaline hydrolysis into the corresponding peptides in good yields (65–93%). From the latter, 4-arylidene-5-oxo-4,5-dihydro-1H-imidazol-1-yl carboxylic acids were obtained using 1,1,1,3,3,3-hexamethyldisilazane as a dehydrating agent. The antiradical and anticholinesterase properties of the synthesized compounds were investigated. UV and fluorescence spectra were studied.