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Abstract <p>Reactions of 2-(4-arylthiazole-2-yl)acetonitriles with 4-methoxybenzylidenemalononitrile and potassium hydroxide or (2<i>E</i>)-3-aryl-2-(4-arylthiazole-2-yl)acrylonitriles with malonitrile and sodium ethylate in ethanol proceeded to form 6-amino-4-aryl-5-(4-arylthiazole-2-yl)-2-ethoxynicotinonitriles with yields of 32–65%. Treatment of 6-amino-2-ethoxy-4-(4-methoxyphenyl)-5-[4-(4-methoxyphenyl)thiazole-2-yl]nicotinonitrile with an excess of molecular bromine produced 6-amino-5-[5-bromo-4-(4-methoxyphenyl)thiazole-2-yl]-2-ethoxy-4-(4-methoxyphenyl)nicotinonitrile with a yield of 45%.</p>

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Synthesis of 6-Amino-4-aryl-5-(4-arylthiazol-2-yl)-2-ethoxynicotinonitriles

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  • 发表日期：

    2025年5月21日

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  • N. A. Pakholka,
  • A. V. Churakov,
  • S. G. Krivokolisko

摘要

Abstract

Reactions of 2-(4-arylthiazole-2-yl)acetonitriles with 4-methoxybenzylidenemalononitrile and potassium hydroxide or (2E)-3-aryl-2-(4-arylthiazole-2-yl)acrylonitriles with malonitrile and sodium ethylate in ethanol proceeded to form 6-amino-4-aryl-5-(4-arylthiazole-2-yl)-2-ethoxynicotinonitriles with yields of 32–65%. Treatment of 6-amino-2-ethoxy-4-(4-methoxyphenyl)-5-[4-(4-methoxyphenyl)thiazole-2-yl]nicotinonitrile with an excess of molecular bromine produced 6-amino-5-[5-bromo-4-(4-methoxyphenyl)thiazole-2-yl]-2-ethoxy-4-(4-methoxyphenyl)nicotinonitrile with a yield of 45%.