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Abstract <p>A short synthesis of a chiral functionally substituted γ-lactone, a structural analogue of acetogenins, was carried out on the basis of diastereomeric Michael adducts of levoglucosenone and α-carboethoxycyclododecanone. Molecular docking of levoglucosenone derivatives was performed. It was shown that the synthesized γ-lactone is capable of binding to tubulin, which indicates its possible antitumor activity.</p>

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Approaches to the Synthesis of Acetogenins Based on the Michael Adducts of Levoglucosenone and α-Carboethoxycyclododecanone and Analysis of Their Biological Activity

  • 期刊论文

  • 发表日期：

    2025年4月25日

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  • Yu. S. Galimova,
  • O. Yu. Kupova,
  • Sh. M. Salikhov,
  • L. Kh. Faizullina

摘要

Abstract

A short synthesis of a chiral functionally substituted γ-lactone, a structural analogue of acetogenins, was carried out on the basis of diastereomeric Michael adducts of levoglucosenone and α-carboethoxycyclododecanone. Molecular docking of levoglucosenone derivatives was performed. It was shown that the synthesized γ-lactone is capable of binding to tubulin, which indicates its possible antitumor activity.