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Abstract <p>Previously, we studied the enantioselective reduction of prochiral saturated aliphatic ketones, catalyzed by available biocatalysts, leading to the formation of the corresponding secondary <i>S</i>-alcohols. In this study, to investigate the synthetic potential of a biocatalyst based on the <i>Petroselinum crispum</i> culture, we explored the possibility of biocatalytic reduction of prochiral unsaturated aliphatic ketones, exemplified by hex-5-en-2-one and 6-methylhept-5-en-2-one, to the respective (<i>S</i>)-(+)-hex-5-en-2-ol and (<i>S</i>)-(+)-6-methylhept-5-en-2-ol, precursors in the synthesis of biologically active substances used in agriculture and medicine.</p>

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Enantioselective Reduction of Hex-5-en-2-one and 6-Methylhept-5-en-2-one, Catalyzed by Petroselinum crispum Cells

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • A. R. Chanysheva,
  • N. V. Privalov,
  • A. N. Shakirov,
  • N. N. Makhmudiyarova,
  • V. V. Zorin

摘要

Abstract

Previously, we studied the enantioselective reduction of prochiral saturated aliphatic ketones, catalyzed by available biocatalysts, leading to the formation of the corresponding secondary S-alcohols. In this study, to investigate the synthetic potential of a biocatalyst based on the Petroselinum crispum culture, we explored the possibility of biocatalytic reduction of prochiral unsaturated aliphatic ketones, exemplified by hex-5-en-2-one and 6-methylhept-5-en-2-one, to the respective (S)-(+)-hex-5-en-2-ol and (S)-(+)-6-methylhept-5-en-2-ol, precursors in the synthesis of biologically active substances used in agriculture and medicine.