Scholarlink

Abstract <p>Natural compounds are actively used as promising starting molecules for the development of new antiviral drugs. In this paper, a method was proposed for the synthesis of new derivatives of bicyclic monoterpenoids using <i>endo</i>- and <i>exo</i>-bornylamines as starting materials. It was shown that alkylation of (+)-<i>exo</i>-bornylamine and (+)- or (–)-<i>endo</i>-bornylamine with 2-chloro-1-morpholinoethanone, 2-chloro-1-(piperidin-1-yl)ethanone and 2-chloro-1-(4-methylpiperidin-1-yl)ethanone in the presence of potassium carbonate as a base leads to the corresponding secondary amines. In order to study the effect of the amide group on the antiviral activity, some of the prepared compounds were reduced to amines. It was found that the <i>exo</i>-bornylamine derivative containing the 4-methylpiperidine fragment has pronounced antiviral activity against the respiratory syncytial virus.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis of Secondary Amines of Bornylamine and Isobornylamine Containing a Saturated N-Heterocycle and Study of Their Antiviral Activity against Respiratory Syncytial Virus

  • 期刊论文

  • 发表日期：

    2025年1月1日

查看全文
  • S. A. Tishchenko,
  • A. S. Sokolova,
  • O. I. Yarovaya,
  • V. I. Krasnov,
  • A. A. Shtro,
  • A. V. Galochkina,
  • A. M. Klabukov,
  • D. N. Razgulyaeva,
  • N. F. Salakhutdinov

摘要

Abstract

Natural compounds are actively used as promising starting molecules for the development of new antiviral drugs. In this paper, a method was proposed for the synthesis of new derivatives of bicyclic monoterpenoids using endo- and exo-bornylamines as starting materials. It was shown that alkylation of (+)-exo-bornylamine and (+)- or (–)-endo-bornylamine with 2-chloro-1-morpholinoethanone, 2-chloro-1-(piperidin-1-yl)ethanone and 2-chloro-1-(4-methylpiperidin-1-yl)ethanone in the presence of potassium carbonate as a base leads to the corresponding secondary amines. In order to study the effect of the amide group on the antiviral activity, some of the prepared compounds were reduced to amines. It was found that the exo-bornylamine derivative containing the 4-methylpiperidine fragment has pronounced antiviral activity against the respiratory syncytial virus.