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Abstract <p>A systematic and efficient green method for the synthesis of advanced derivatives of isoxazole at room temperature was developed using ferrite as a catalyst. This process involves a simple one-pot multicomponent reaction of aromatic aldehydes, ethyl acetoacetate and hydroxylamine in a green solvent. The reaction time was significantly reduced by employing ultrasonic waves as an energy source. Key features of this protocol include a straightforward workup procedure, mild reaction conditions, the use of a green solvent, reusability of the catalyst and a developed synthesis that eliminates the need for purification steps such as chromatography.</p>

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Ultrasound-Promoted Ferrite Catalyzed One-Pot Multicomponent Synthesis of 3,4-Disubstituted Isoxazole-5(4H)-one Derivatives in Water as a Green Solvent with Evaluation of Antimicrobial Activity

  • 期刊论文

  • 发表日期：

    2025年3月27日

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  • S. S. Ghevade,
  • S. B. Kamble,
  • K. N. Patil,
  • V. S. Ingale,
  • D. A. Kumbhar

摘要

Abstract

A systematic and efficient green method for the synthesis of advanced derivatives of isoxazole at room temperature was developed using ferrite as a catalyst. This process involves a simple one-pot multicomponent reaction of aromatic aldehydes, ethyl acetoacetate and hydroxylamine in a green solvent. The reaction time was significantly reduced by employing ultrasonic waves as an energy source. Key features of this protocol include a straightforward workup procedure, mild reaction conditions, the use of a green solvent, reusability of the catalyst and a developed synthesis that eliminates the need for purification steps such as chromatography.