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Abstract <p>A series of novel triazole functionalized quinazolinone derivatives were synthesized starting from 2-amino-6-(trifluoromethyl)benzonitrile. All the final compounds were evaluated for anticancer activity against four human cancer cell lines such as HeLa—cervical cancer (CCL-2), COLO 205—colon cancer (CCL-222), HepG2—liver cancer (HB-8065), MCF7—breast cancer (HTB-22), and promising compounds have been identified. Two compounds were further evaluated for molecular docking interactions.</p>

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Novel Triazole Functionalized Quinazolinone Derivatives, Their Anticancer Activity, and Docking Interactions

  • 期刊论文

  • 发表日期：

    2025年4月25日

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  • B. Udayasri,
  • P. Naveen,
  • B. Sailu

摘要

Abstract

A series of novel triazole functionalized quinazolinone derivatives were synthesized starting from 2-amino-6-(trifluoromethyl)benzonitrile. All the final compounds were evaluated for anticancer activity against four human cancer cell lines such as HeLa—cervical cancer (CCL-2), COLO 205—colon cancer (CCL-222), HepG2—liver cancer (HB-8065), MCF7—breast cancer (HTB-22), and promising compounds have been identified. Two compounds were further evaluated for molecular docking interactions.