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Abstract <p>The intramolecular reductive Heck reaction of <i>o</i>-bromobenzoic acid enamides under catalysis by Pd(OAc)<sub>2</sub>/(<i>R</i>)-C<sub>3</sub>-Tunephos serves as a convenient approach to the synthesis of enantiomerically enriched 3,3-disubstituted isoindoline-1-ones (up to <i>ee</i> 90%).</p>

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Asymmetric Synthesis of Isoindolin-1-ones from Enamides via Pd-Catalyzed Intramolecular Reductive Heck Reaction

  • 期刊论文

  • 发表日期：

    2025年1月1日

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  • M. A. Ashatkina,
  • D. I. Shamshina,
  • V. A. Shiryaev,
  • S. Yu. Vostruhina,
  • A. N. Reznikov,
  • Yu. N. Klimochkin

摘要

Abstract

The intramolecular reductive Heck reaction of o-bromobenzoic acid enamides under catalysis by Pd(OAc)2/(R)-C3-Tunephos serves as a convenient approach to the synthesis of enantiomerically enriched 3,3-disubstituted isoindoline-1-ones (up to ee 90%).