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Abstract <p>A straightforward and effective method for the synthesis of new series of benzimidazole-triazole hybrids developed by adopting click Cu(I)-catalyzed 1,3-dipolar cycloaddition. Alkyne tethered benzimidazole carboxylates treated with various aromatic azides using sodium ascorbate and copper sulphate as catalytic medium. The resulting series of novel benzimidazole-linked 1,2,3-triazole analogues were characterized using NMR, IR, mass spectral data. All the compounds screened for cytotoxic and antimicrobial activity. Three compounds exhibited good cytotoxic as well as antimicrobial activity</p>

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Synthesis of Novel Substituted 4-[1-(1-Phenyl-1H-[1,2,3]triazol-4-yl-methyl)-1H-benzimidazol-2-yl]piperidine-1-carboxylic Acids tert-Butyl Esters. Evaluation of Cytotoxic and Antimicrobial Activity

  • 期刊论文

  • 发表日期：

    2025年3月27日

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  • P. Naresh,
  • Y. Hemasri,
  • P. Limbadri,
  • Y. Jayaprakash Rao

摘要

Abstract

A straightforward and effective method for the synthesis of new series of benzimidazole-triazole hybrids developed by adopting click Cu(I)-catalyzed 1,3-dipolar cycloaddition. Alkyne tethered benzimidazole carboxylates treated with various aromatic azides using sodium ascorbate and copper sulphate as catalytic medium. The resulting series of novel benzimidazole-linked 1,2,3-triazole analogues were characterized using NMR, IR, mass spectral data. All the compounds screened for cytotoxic and antimicrobial activity. Three compounds exhibited good cytotoxic as well as antimicrobial activity