Scholarlink

Abstract <p>This research aims to elucidate the structural features and reactivity of these complexes, shedding light on their significance in advancing the field of transition metal coordination chemistry as well as their potential biological screening applications. A Schiff base ligand with tridentate pyridine, denoted as (<i>E</i>)-<i>N</i>′-(arylidene)-2-methyl-6-(4-nitrophenyl)nicotine hydrazide, was derived from 2-methyl-6-(4-nitrophenyl)nicotine hydrazide and various substituted salicylaldehyde in a 1 : 1 molar ratio. The synthesis of all Schiff bases employed the microwave-assisted irradiation method. Furthermore, Pd(II), Co(II) and Ni(II) metal complexes of these ligands were synthesized through a conventional method. The ligands and their complexes underwent characterization using various analytical techniques such as MS, FT-IR, <sup>1</sup>H, <sup>13</sup>C NMR, thermogravimetric analysis and other methods. Analysis of spectral data disclosed unique metal-ligand stoichiometric ratios, where the Co(II) and Ni(II) complexes displayed a 1 : 2 ratio, while the Pd(II) complex exhibited a 1 : 1 ratio. In addition, synthesized compounds screened against gram-positive, gram-negative and fungal stains for their antimicrobial assay using the broth dilution method and ciprofloxacin and nystatin were used as standards. Synthesized Ni(II) and Pd(II) complexes demonstrated outstanding inhibitory activity against the bacterial strain, exhibiting MIC values of 25 and 50 µg/mL, surpassing the efficacy of ciprofloxacin. Similarly, compound of Co(II) complex exhibited remarkable inhibitory activity against the antifungal strain, with a MIC of 125 µg/mL, outperforming Nystatin.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Microwave-Assisted Synthesis of 2-Methyl-6-(4-nitrophenyl)nicotine Hydrazide Schiff Base Analogues: Design, Synthesis, and Characterization of Their Metal Complexes and In Vitro Biological Screening

  • 期刊论文

  • 发表日期：

    2025年6月1日

查看全文
  • P. Unjiya,
  • U. Patel,
  • H. Parmar,
  • M. Mamtora,
  • M. Shah

摘要

Abstract

This research aims to elucidate the structural features and reactivity of these complexes, shedding light on their significance in advancing the field of transition metal coordination chemistry as well as their potential biological screening applications. A Schiff base ligand with tridentate pyridine, denoted as (E)-N′-(arylidene)-2-methyl-6-(4-nitrophenyl)nicotine hydrazide, was derived from 2-methyl-6-(4-nitrophenyl)nicotine hydrazide and various substituted salicylaldehyde in a 1 : 1 molar ratio. The synthesis of all Schiff bases employed the microwave-assisted irradiation method. Furthermore, Pd(II), Co(II) and Ni(II) metal complexes of these ligands were synthesized through a conventional method. The ligands and their complexes underwent characterization using various analytical techniques such as MS, FT-IR, 1H, 13C NMR, thermogravimetric analysis and other methods. Analysis of spectral data disclosed unique metal-ligand stoichiometric ratios, where the Co(II) and Ni(II) complexes displayed a 1 : 2 ratio, while the Pd(II) complex exhibited a 1 : 1 ratio. In addition, synthesized compounds screened against gram-positive, gram-negative and fungal stains for their antimicrobial assay using the broth dilution method and ciprofloxacin and nystatin were used as standards. Synthesized Ni(II) and Pd(II) complexes demonstrated outstanding inhibitory activity against the bacterial strain, exhibiting MIC values of 25 and 50 µg/mL, surpassing the efficacy of ciprofloxacin. Similarly, compound of Co(II) complex exhibited remarkable inhibitory activity against the antifungal strain, with a MIC of 125 µg/mL, outperforming Nystatin.