New Approaches to Chiral Separation by Means of Capillary Electrophoresis (A Review)

The ease of varying the conditions of electrophoretic separation and the possibility of using a wide variety of chiral selectors make the capillary electrophoresis method a promising alternative to high-performance liquid chromatography for the separation of racemic drugs. This review summarizes the main directions of development of electrophoretic methods for enantiomeric analysis of biologically active compounds, including the use of various modifiers of the quartz capillary walls and background electrolyte (cyclodextrins, nanoparticles, ionic liquids, etc.), formation of multilayer coatings, and combining of enantiomeric analysis with online derivatization and preconcentration of analytes.