Antibacterial Activity and Mechanism of Action of New Benzylamine-Containing Coumarin Derivatives
摘要
Abstract
A series of novel coumarin derivatives was successfully synthesized by combining the coumarin skeleton with a benzylamine moiety. These derivatives showed better antibacterial activities in vitro tests, especially compound, which was particularly effective. The mechanism of the antibacterial action of compound was thoroughly investigated, and the experimental results revealed that compound was able to increase the permeability of bacterial cell membranes, leading to the disruption of Xoc membranes and effectively inhibiting bacterial growth and reproduction. This finding not only elucidates the antibacterial mechanism of compound, but also provides an important scientific basis for the development of new antibacterial agents in the future.