Synthesis of Quinine Ester of Naproxen and Study of Its Photophysical Properties

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发表日期：

2024年12月1日

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I. N. Egorov,
M. I. Valieva,
D. S. Kopchuk,
I. S. Kovalev,
G. V. Zyryanov

摘要

Abstract

Quinine Ester of Naproxen was obtained for the first time by O-acylation of quinine with naproxen [(S)-6-methoxy-α-methyl-2-naphthaleneacetic acid] chloride under alkaline conditions. The structure of the product was proved by ¹H NMR. The photophysical properties of the resulting compound were studied, an intense fluorescent response to picric acid with a Stern–Volmer constant K_sv ≈ 1×10⁶ M^–1 was shown.