Complexes of Anionic and Cationic Liposomes for Encapsulation of Bioactive Substances

Multiliposomal nanocontainers were obtained by electrostatic adsorption of anionic liposomes on the surface of the carrier- PEG-coated cationic liposomes. The composition of liposomes was estimated, that lead to the formation of multiliposomal complexes of the 200–400 nm size with preserved integrity of the lipid bilayer. The degradation of the complexes under the action of lipase was followed by a quantitative release of incapsulated substance. The complexes seem to be promising for biomedical applications.