Synthesis and Antiglycation Activity of Pyridoxine Azo Derivatives

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发表日期：

2024年11月1日

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A. D. Strelnik,
M. A. Belova,
O. S. Vasilieva,
E. M. Fafanova,
O. I. Gnezdilov,
S. A. Ivanov,
T. V. Nikishova,
Y. V. Badeev,
E. A. Ocherednyuk,
V. A. Burilov,
D. Y. Grishaev,
M. N. Agafonova,
Y. G. Shtyrlin

摘要

Abstract

An approach to the synthesis of pyridoxine azo derivatives based on aminophenols was developed. 52 new pyridoxine derivatives were synthesized. An in vitro study of antiglycation properties showed that most of the prepared pyridoxine azo derivatives (IC₅₀ = 10–191 μM) significantly exceed the phase I-II clinical trials drugs aminoguanidine (IC₅₀ = 526 μM) and pyridoxamine (IC₅₀ = 834 μM) in their activity. Some of the obtained compounds also have high antioxidant activity and effectively inhibit lipid peroxidation.