Synthesis and Biological Properties of Hybrid Compounds Based on Nitrogen-Containing Heterocycles and 1,5-Disubstituted 3,7-Diazabicyclo[3.3.1]nonan-9-ones

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发表日期：

2024年11月1日

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A. A. Harutyunyan,
S. G. Israelyan,
M. R. Hakobyan,
M. S. Safaryan,
R. A. Madoyan,
A. G. Sukiasyan,
K. A. Gevorkyan,
A. D. Harutyunyan,
A. S. Sargsyan,
A. A. Hambardzumyan,
H. A. Karapetyan,
A. A. Mnatsakanyan,
H. A. Panosyan,
M. Yu. Danghyan,
S. P. Gasparyan

摘要

Abstract

The reaction of aromatic aldehydes and 3-(heteryl)methyl-4-methoxybenzaldehydes with 1,5-disubstituted 3,7-diazabicyclo[3.3.1]nonan-9-ones afforded 2-aryl(hetaryl)-5,7-dimethyl-1,3-diazaadamantane-6-ones. 3-(Heteryl)methyl-4-methoxybenzaldehydes were obtained by alkylation of nitrogen-containing heterocycles (N¹-functionalized uracil and 5-halouracils, N³-functionalized 6-methylpyrimidin- and quinazolin-4(3H)-ones, benzotriazole, quinoline, benzoxazole) with 3-chloromethyl-4-methoxylbenzaldehyde. Antibacterial and fungicidal properties of the synthesized compounds were studied.