Regioselective Nitration of (2E)-3-Aryl-2-(4-arylthiazol-2-yl)acrylonitriles

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发表日期：

2024年10月1日

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N. A. Pakholka,
V. V. Dotsenko,
N. А. Aksenov,
I. V. Aksenova,
S. G. Krivokolysko

摘要

Abstract

The reaction of (2E)-3-aryl-2-(4-aryl-1,3-thiazol-2-yl)acrylonitriles with an excess of nitric acid in AcOH proceeds regioselectively to afford previously unknown (2E)-3-aryl-2-(4-aryl-5-nitro-1,3-thiazol-2-yl)acrylonitriles in 82–96% yields.