Synthesis, Biological Evaluation, and Molecular Docking Studies of 7-Azaindole-Acylsulfonamide Derivatives as Mcl-1 Inhibitors
摘要
Abstract
A series of 7-azaindole-acylsulfonamide derivatives was designed, synthesized and evaluated for inhibitory activity against Mcl-1 protein through fluorescence polarization assays (FPAs). Among them, the most potent compounds showed the best inhibitory activities against Mcl-1 with the inhibitory rate of 97% at the concentration of 50 μM, which was a little more potent than the positive control WL-276 (95%).