Urease Inhibition Activity Studies of Novel Azabenzimidazole-Derived Compounds

A new series of azabenzimidazole compounds was synthesized and characterized with spectral methods such as IR, ¹H NMR, ¹³C NMR and elemental analysis. The target compounds were screened for urease, and acetylcholinesterase inhibitory activities. The synthesized azabenzimidazole containing thiosemicarbazide and oxadiazole moieties showed antiurease activity. 2,2′-[(6-Bromo-2-oxo-1H-imidazo[4,5-b]pyridine-1,3-diyl)bis(1-oxoethane-2,1-diyl)]bis(N-4-nitrophenylhydrazinecarbothioamide) has the best inhibition result with IC₅₀ = 15.80±0.40 µg/mL (15.75±0.15 µg/mL for thiourea).