Reactions of 1,2-Diones with 3-Aminopyridine

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发表日期：

2024年9月1日

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S. E. Vatolina,
A. P. Krinochkin,
A. A. Yurtaeva,
A. S. Alekseeva,
A. S. Markina,
M. I. Valieva,
V. V. Nadtochiy,
O. V. Shabunina,
D. S. Kopchuk,
G. V. Zyryanov

摘要

Abstract

The reactions of 3-aminopyridine with 9,10-phenanthrenequinone and 1,2-naphthoquinone under various conditions was studied. The formation of the monoimine was observed in the presence of an additional aromatic ring in the structure of the starting dione. The product of the nucleophilic attack of the amino group at position C4 of the aromatic ring was obtained in the absence of this additional ring. One of the products obtained is a derivative of lawsone, a natural dye with a wide range of bioactivity, including antitumor one. Its structure was additionally confirmed by single crystal X-ray diffraction analysis.