Synthesis and Antitumor Activity of Hybrid Compounds Based on Aryl-Substituted Isatins and 2-Chloroethynyl (4-(Dimetylamino)phenyl)(2-hydrazinyl-2-oxoethyl)phosphinate

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发表日期：

2024年8月1日

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A. V. Bogdanov,
A. A. Ivanova,
A. D. Voloshina,
R. R. Rakhmatullin,
A. V. Samorodov,
Z. A. Valiullina,
I. D. Krylova,
S. V. Bukharov

摘要

Abstract

New phosphorus-containing isatin-3-hydrazones were synthesized by the condensation reaction of 5-substituted isatins with 2-chloroethyl [4-(dimethylamino)phenyl](2-hydrazinyl-2-oxoethyl)phosphinate (KAPAKh). The resulting compounds were shown to have high antitumor activity against duodenal adenocarcinoma (HuTu80) and cervical epithelioid carcinoma (M-HeLa) cell lines with low toxicity towards erythrocytes and normal human liver cells.