New Features of the H2SO4–HNO3 System in the Synthesis of Adamantanecarboxylic Acids
摘要
Abstract
New methods for the direct preparation of 3-hydroxy-1-adamantanecarboxylic acid and 1,3-adamantanedicarboxylic acid from 1-adamantyl halides was developed. The one-pot methods are based on the sequential combination of the Koch–Haaf and oxidation reactions in a H2SO4–HNO3 mixture. This study proposes an improved method for the preparation of 1-adamantanecarboxylic acids from 1-adamantyl halides.