Oxidative Dimerization of (Thiazol-2-yl)acetonitriles with Molecular Iodine: Synthesis and Structure of 2,3-Bis(4-aryl-1,3-thiazol-2-yl)but-2-enedinitriles

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2024年7月1日

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V. L. Abramenko,
S. G. Krivokolysko,
N. A. Pakholka,
B. S. Krivokolysko,
V. V. Dotsenko,
A. V. Bespalov,
N. А. Aksenov,
I. V. Aksenova

摘要

Abstract

Iodination of 2-(4-arylthiazole-2-yl)acetonitriles in DMF proceeds with the formation of previously undescribed 2,3-bis(4-aryl-1,3-thiazole-2-yl)but-2-enedicarbonitriles as a mixture of E- and Z-isomers. The latter were alternatively prepared by the reaction of cyanothioacetamide, α-bromoketones and iodine in DMF. Structure of the key compounds was proven by means of single crystal X-ray diffraction analysis.