Synthesis and Antimicrobial Properties of Quaternary Ammonium Salts with Two Propargyl Groups

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发表日期：

2024年7月1日

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V. S. Hovsepyan,
A. V. Babakhanyan,
K. V. Balyan,
N. A. Harutyunyan,
Sh. G. Khamisyan,
N. G. Hobosyan,
H. B. Sargsyan

摘要

Abstract

Several dipropargylic quaternary ammonium salts were synthesized by the reaction of methyldipropargylamine with alkyl esters (C₈-C₁₂) of chloroacetic acid or haloalkanes with the number of carbon atoms C₈–C₁₀. The synthesized N-methyl-N,N-di(prop-2-yn-1-yl)alkan-1-ammonium halides (bromide and iodides), and N-(2-(alkoxy)-2-oxoethyl)-N-methyl-N-(prop-2-yn-1-yl)prop-2-yn-1-ammonium chlorides exhibit high antibacterial activity against gram-positive (Stаphylococcus aureus 209p and Bacillus subtilis 6633), gram-negative (Shigella Flexneri 6858 and Escherichia coli 0-55) microorganisms and antifungal activity against (Candida Albicans, Saccharomyces cerevisiae, and Saccharomyces boulardii).