Novel Oxo-5-(trifluoromethyl)quinazolinyl Amide Derivatives, Their Anticancer Activity and Docking Interactions

A series of novel oxo-5-(trifluoromethyl)quinazolinyl amide derivatives were prepared starting from 2-aminobenzoic acid, reacted with 4-chlorobenzoyl chloride and obtained 2-(4-chlorophenyl)-5-(trifluoromethyl)-4H-benzo[d][1,3]oxazin-4-one, further on reaction with hydroxyl amine and obtained 2-(4-chlorophenyl)-3-(4-hydroxyphenyl)-5-(trifluoromethyl)-quinazolin-4(3H)-one, this compound on further react with ethyl bromoacetate to get ethyl 2-{4-[2-(4-chlorophenyl)-4-oxo-5-(trifluoromethyl)quinazolin-3(4H)-yl]phenoxy}acetate, further treated with aliphatic and aryl amine to obtain amide functionalized quinazoline derivatives. All the final compounds evaluated for anticancer activity against four human cancer cell lines such as HeLa – cervical cancer (CCL-2), COLO 205 – colon cancer (CCL-222), HepG2 – liver cancer (HB-8065), MCF7 – breast cancer (HTB-22) and promising compounds have been identified, and evaluated for docking interactions.