Synthesis and Some Properties of Thiocarbamoylpyrazoles

New derivatives of 3-R-5-chloromethyl-1-thiocarbamoylpyrazole have been synthesized by the intramolecular heterocyclization of thiosemicarbazones of unsaturated ketones, obtained by the interaction of 3,4-dichlorobut-2-ene-1-ones with thiosemicarbazide, in a dioxane with a twofold excess of pyridine. The biological activity of a series of the synthesized substances in vitro has been studied and it has been revealed that the synthesized functional derivatives of pyrazoles show more expressed antimicrobial properties in relation to Staphylococcus aureus, Bacillus cereus, Escherichia coli and Candida albicans.