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Abstract <p>A new iridium(III) complex with cyclometallating benzothiophenylpyridyl ligands and an additional norbornene-substituted picolinate ligand NBEpicIr(Btp)<sub>2</sub> (<b>I</b>) (NBEpicH is 3-(((1<i>S</i>,4<i>S</i>)-bicyclo[2.2.1]hept-5-ene-2-carbonyl)oxy)picolinic acid, and BtpH is benzothiophenylpyridine) is synthesized. The structures of the iridium-containing reagents (Btp)<sub>2</sub>IrCl(DMSO-d<sub>6</sub>) (<b>II</b>) and (Btp)<sub>2</sub>IrCl(DMSO) (<b>III</b>) are determined by X-ray diffraction (XRD) (CIF files CCDC nos. 2456556 and 2456557, respectively). Polymer sensor P1 is synthesized from norbornene-containing iridium complex <b>I</b> using metathesis polymerization. Polymer sensor P1 has a low cytotoxicity, penetrates into tumor cells, and can be used for measuring oxygen content in tumors.</p>

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Cyclometallated Iridium(III) Complex with Benzothiophenylpyridyl and Norbornene-Substituted Picolinate Ligands and Related Water-Soluble Polymer: Synthesis and Photophysical and Biological Properties

  • 期刊论文

  • 发表日期：

    2026年1月1日

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  • L. N. Bochkarev,
  • Yu. P. Parshina,
  • E. V. Baranov,
  • T. A. Kovylina,
  • A. N. Konev,
  • A. D. Komarova,
  • V. V. Elagin,
  • M. V. Shirmanova

摘要

Abstract

A new iridium(III) complex with cyclometallating benzothiophenylpyridyl ligands and an additional norbornene-substituted picolinate ligand NBEpicIr(Btp)2 (I) (NBEpicH is 3-(((1S,4S)-bicyclo[2.2.1]hept-5-ene-2-carbonyl)oxy)picolinic acid, and BtpH is benzothiophenylpyridine) is synthesized. The structures of the iridium-containing reagents (Btp)2IrCl(DMSO-d6) (II) and (Btp)2IrCl(DMSO) (III) are determined by X-ray diffraction (XRD) (CIF files CCDC nos. 2456556 and 2456557, respectively). Polymer sensor P1 is synthesized from norbornene-containing iridium complex I using metathesis polymerization. Polymer sensor P1 has a low cytotoxicity, penetrates into tumor cells, and can be used for measuring oxygen content in tumors.