Scholarlink

Abstract <p>Copper(II) and zinc complexes with 1,3-bis((pyridin-2-yl)-1,2,4-triazolyl)propane (L<sup>1</sup>) and 1,4-bis((pyridin-2-yl)-1,2,4-triazolyl)butane (L<sup>2</sup>) were synthesized and investigated. The composition and structure of the complexes were studied by elemental and thermogravimetric analysis, ESI mass spectrometry, IR spectroscopy, and X-ray diffraction. The complexes were found to have the composition [MLX]X·<i>n</i>H<sub>2</sub>O (X&#xa0;= Cl, Br; <i>n</i> = 3–5) and mononuclear cationic structure. The complex [Cu(L<sup>2</sup>)Cl]Cl·2.5H<sub>2</sub>O exhibited a high antibacterial activity against luminescent test bacteria (<i>Photobacterium leiognathi</i> Sh1 and <i>Aliivibrio fischeri</i> F1) and also proved to be highly toxic against rapidly growing human cells. The ligand L<sup>2</sup> was identified as a promising chemical structure for the development of antibacterial agents, both organic compounds and metal complexes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Antibacterial and Cytotoxic Properties of Zinc and Copper(II) Coordination Compounds with Bis((pyridin-2-yl)-1,2,4-triazolyl)alkanes

  • 期刊论文

  • 发表日期：

    2026年1月1日

查看全文
  • A. B. Kiyaev,
  • S. L. Safronyuk,
  • I. M. Samokhvalov,
  • K. S. Zakharov,
  • A. N. Gusev,
  • A. M. Katsev,
  • M. A. Kiskin

摘要

Abstract

Copper(II) and zinc complexes with 1,3-bis((pyridin-2-yl)-1,2,4-triazolyl)propane (L1) and 1,4-bis((pyridin-2-yl)-1,2,4-triazolyl)butane (L2) were synthesized and investigated. The composition and structure of the complexes were studied by elemental and thermogravimetric analysis, ESI mass spectrometry, IR spectroscopy, and X-ray diffraction. The complexes were found to have the composition [MLX]X·nH2O (X = Cl, Br; n = 3–5) and mononuclear cationic structure. The complex [Cu(L2)Cl]Cl·2.5H2O exhibited a high antibacterial activity against luminescent test bacteria (Photobacterium leiognathi Sh1 and Aliivibrio fischeri F1) and also proved to be highly toxic against rapidly growing human cells. The ligand L2 was identified as a promising chemical structure for the development of antibacterial agents, both organic compounds and metal complexes.