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Abstract <p>The reaction of zinc(II) nitrate with 2-ferrocenyl-1,10-phenanthroline (L) produced the complex [ZnL(NO<sub>3</sub>)<sub>2</sub>] (<b>I</b>), which was analyzed by elemental analysis, powder X-ray diffraction, thermogravimetric analysis, cyclic voltammetry, and IR spectroscopy. According to the single-crystal X-ray diffraction analysis, the coordination environment of zinc(II) can be described as 5 + 1, and L acts as a chelating ligand that binds to the zinc(II) atom through the nitrogen atoms of the phenanthroline moiety. The cytotoxic properties of complex <b>I</b> were evaluated using the human two-dimensional cell lines Hep2 (laryngeal carcinoma cells), A549 (lung adenocarcinoma cells), and MRC5 (nontumor lung fibroblasts). Complex <b>I</b> exhibited cytotoxicity at concentrations between 50 and 100 μM. The activity of complex <b>I</b> in Hep2 spheroids (3D model) was found to be comparable to that in the two-dimensional model. The behavior of the complex in solution was studied using optical spectroscopy, conductometry, and cyclic voltammetry.</p>

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Zinc(II) Complex with 2-Ferrocenyl-1,10-phenanthroline: Synthesis, Structure, Study of Electrochemical and Cytotoxic Properties

  • 期刊论文

  • 发表日期：

    2025年10月1日

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  • E. A. Ermakova,
  • Yu. A. Golubeva,
  • K. S. Smirnova,
  • P. E. Savinykh,
  • N. F. Romashev,
  • L. S. Klyushova,
  • E. Yu. Zyryanova,
  • I. A. Utepova,
  • E. V. Lider

摘要

Abstract

The reaction of zinc(II) nitrate with 2-ferrocenyl-1,10-phenanthroline (L) produced the complex [ZnL(NO3)2] (I), which was analyzed by elemental analysis, powder X-ray diffraction, thermogravimetric analysis, cyclic voltammetry, and IR spectroscopy. According to the single-crystal X-ray diffraction analysis, the coordination environment of zinc(II) can be described as 5 + 1, and L acts as a chelating ligand that binds to the zinc(II) atom through the nitrogen atoms of the phenanthroline moiety. The cytotoxic properties of complex I were evaluated using the human two-dimensional cell lines Hep2 (laryngeal carcinoma cells), A549 (lung adenocarcinoma cells), and MRC5 (nontumor lung fibroblasts). Complex I exhibited cytotoxicity at concentrations between 50 and 100 μM. The activity of complex I in Hep2 spheroids (3D model) was found to be comparable to that in the two-dimensional model. The behavior of the complex in solution was studied using optical spectroscopy, conductometry, and cyclic voltammetry.