Abstract <p>The excitation functions of proton-induced reactions on natural tin ^natSn(<i>p</i>,&#xa0;<i>x</i>)^{118m;120m;122;124}Sb and ^113;117mSn, were investigated using statistical nuclear codes TALYS 1.96 and EMPIRE 3.2. Various models were implemented in these codes for the proton energy range from reaction thresholds to 70 MeV. A comparison of theoretical calculations, utilizing different models of the TALYS 1.96 and EMPIRE 3.2 codes, with experimental data from the EXFOR database was performed. The experimental data were compared with theoretical results through statistical analysis. Weighted statistical parameters of relative deviation were used to assess the differences between experimental and theoretical cross-section values and to evaluate the reliability of the codes. The importance of this study is determined by the practical applications of the ¹²⁴Sb, ¹²²Sb, and ^117mSn isotopes.</p>