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Abstract <p><b>Objective:</b> Dysregulation of tryptophan metabolism can play a significant role in the pathogenesis of various diseases, including chronic kidney diseases, among which immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulopathy in young and middle-aged people. Analysis of tryptophan metabolism disorders may be useful for precision diagnosis of IgAN and identification of additional molecular targets for disease therapy. <b>Methods:</b> High-performance liquid chromatography with mass spectrometric detection was used to measure the concentrations of tryptophan and its metabolites: 5-hydroxytryptophan, kynurenine, kynurenic, indoleacetic, and indolelactic acids in blood serum samples from patients diagnosed with IgAN with disease activity (IgAN-A, <i>n</i> = 85) and in remission (IgAN-R, <i>n</i> = 28), as well as in blood serum samples from healthy volunteers (K1, <i>n</i> = 33) and patients with other kidney diseases (K2, <i>n</i> = 31). Untargeted and targeted metabolomic analysis were performed. <b>Results and Discussion:</b> Untargeted and targeted metabolomic analysis showed that significant changes in tryptophan metabolism in IgAN are associated with activation of the kynurenine and serotonin pathways. <b>Conclusions:</b> The conducted exploratory study indicates the need for additional research to study the relationship between the pathogenesis of IgAN and tryptophan metabolism.</p>

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Alterations of Tryptophan Metabolism Pathways in Immunoglobulin A Nephropathy: an Exploratory Study

  • 期刊论文

  • 发表日期：

    2026年7月2日

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  • E. I. Savelieva,
  • M. D. Shachneva,
  • T. I. Alyushina,
  • Z. K. Kochoyan,
  • O. V. Galkina,
  • V. A. Dobronravov

摘要

Abstract

Objective: Dysregulation of tryptophan metabolism can play a significant role in the pathogenesis of various diseases, including chronic kidney diseases, among which immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulopathy in young and middle-aged people. Analysis of tryptophan metabolism disorders may be useful for precision diagnosis of IgAN and identification of additional molecular targets for disease therapy. Methods: High-performance liquid chromatography with mass spectrometric detection was used to measure the concentrations of tryptophan and its metabolites: 5-hydroxytryptophan, kynurenine, kynurenic, indoleacetic, and indolelactic acids in blood serum samples from patients diagnosed with IgAN with disease activity (IgAN-A, n = 85) and in remission (IgAN-R, n = 28), as well as in blood serum samples from healthy volunteers (K1, n = 33) and patients with other kidney diseases (K2, n = 31). Untargeted and targeted metabolomic analysis were performed. Results and Discussion: Untargeted and targeted metabolomic analysis showed that significant changes in tryptophan metabolism in IgAN are associated with activation of the kynurenine and serotonin pathways. Conclusions: The conducted exploratory study indicates the need for additional research to study the relationship between the pathogenesis of IgAN and tryptophan metabolism.