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Abstract <p><b>Objective:</b> To synthesize and characterize a new series of CF<sub>3</sub>-substituted benzothiazepines and evaluate their anticancer activity. <b>Methods:</b> The compounds <b>5a–5n</b> were synthesized and characterized using FT-IR, NMR spectroscopy, and elemental analysis. Their anticancer activity was evaluated against A549, MCF-7, and HepG2 cell lines using the SRB assay. <b>Results and Discussion:</b> The compounds demonstrated moderate to good activity against all tested cell lines. Notably, compound <b>5j</b> showed significant activity against all three cell lines. <b>Conclusions:</b> These findings highlight the potential of this series for the development of novel anticancer agents.</p>

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CF3-Substituted Benzothiazepines as Promising Anticancer Agents

  • 期刊论文

  • 发表日期：

    2026年1月22日

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  • Jasmin J. Uparkar,
  • Ashwin A. Chalke,
  • Suresh D. Pawar

摘要

Abstract

Objective: To synthesize and characterize a new series of CF3-substituted benzothiazepines and evaluate their anticancer activity. Methods: The compounds 5a–5n were synthesized and characterized using FT-IR, NMR spectroscopy, and elemental analysis. Their anticancer activity was evaluated against A549, MCF-7, and HepG2 cell lines using the SRB assay. Results and Discussion: The compounds demonstrated moderate to good activity against all tested cell lines. Notably, compound 5j showed significant activity against all three cell lines. Conclusions: These findings highlight the potential of this series for the development of novel anticancer agents.