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Abstract <p><b>Objective:</b> The development of effective antiviral agents targeting whitefly-transmitted begomoviruses using a one-pot multicomponent reaction (MCR) approach. <b>Methods:</b> The synthesis was performed <i>via</i> a one-pot multicomponent reaction of aryl aldehydes, thiourea, and ethyl cyanoacetate in an ethanolic solution of potassium carbonate. The compounds were characterized using <sup>1</sup>H, <sup>13</sup>C NMR, FT-IR spectroscopy, and mass spectrometry. <i>In vivo</i> antiviral studies of the resulting compounds were conducted against whitefly-transmitted begomovirus using simultaneous, protective, and curative approaches. <b>Results and Discussion:</b> The results revealed that the synthesized derivative 6-(4-chlorophenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile <b>IVa</b> exhibited the best antiviral activity at 125 µg/mL in the protective approach. <b>Conclusions:</b> The synthesized compound <b>IVa</b> shows promising antiviral activity and could be considered for further development.</p>

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One-Pot Multicomponent Synthesis of Uracil Derivatives and Their Antiviral Activity

  • 期刊论文

  • 发表日期：

    2025年12月1日

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  • K. Jain,
  • S. Sharma,
  • A. Sharma,
  • D. Utreja

摘要

Abstract

Objective: The development of effective antiviral agents targeting whitefly-transmitted begomoviruses using a one-pot multicomponent reaction (MCR) approach. Methods: The synthesis was performed via a one-pot multicomponent reaction of aryl aldehydes, thiourea, and ethyl cyanoacetate in an ethanolic solution of potassium carbonate. The compounds were characterized using 1H, 13C NMR, FT-IR spectroscopy, and mass spectrometry. In vivo antiviral studies of the resulting compounds were conducted against whitefly-transmitted begomovirus using simultaneous, protective, and curative approaches. Results and Discussion: The results revealed that the synthesized derivative 6-(4-chlorophenyl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile IVa exhibited the best antiviral activity at 125 µg/mL in the protective approach. Conclusions: The synthesized compound IVa shows promising antiviral activity and could be considered for further development.