Scholarlink

Abstract <p>This review provides information on the systematics, distribution, composition of metabolites, and biological activity of plants of the <i>Taxaceae</i> S.F.Gray family, comprising eight genera. According to taxonomists, the family has 30–35 species, most of which are endemic to Asia. Across the globe medicine, since the 1990s, the <i>Taxaceae</i> family has been known for the preparations Paclitaxel®, Docetaxel®, and Synribo® with antitumor effect, produced from some species of this family. In traditional Indian (Ayurveda) medicine, Tibetan medicine, and Chinese medicine, various parts of <i>Taxus baccata, Taxus wallichiana, Cephalotaxus hainanensis, Cephalotaxus mannii,</i> and <i>Torreya grandis</i> are used. The most extensively studied are the antitumor properties and composition of metabolites of some of the 17 species of the <i>Taxaceae</i> family: <i>Taxus brevifolia, Taxus baccata, Taxus cuspidata, Taxus wallichiana, Taxus yunnanensis, Torreya nucifera, Torreya grandis, Cephalotaxus wilsoniana, Cephalotaxus sinensis, Cephalotaxus oliveri, Cephalotaxus lanceolata, Cephalotaxus koreana, Cephalotaxus harringtonia, Cephalotaxus hainanensis, Cephalotaxus griffithii, Cephalotaxus fortunei,</i> and <i>Amentotaxus formosana</i>. In the studied species, over 900 substances belonging to different classes of chemical compounds were identified: alkaloids, terpenoids, fatty acids, phenolic compounds (simple phenols, phenolic carboxylic acids, flavonoids, tannins), vitamins, lignans, sterols, amino acids, etc. An important marker of the family is probably taxane diterpenes, which were found in the 17 species of the <i>Taxaceae</i> family. According to the literature, this group of substances, as well as alkaloids, are decisive in the antitumor effect exerted by <i>Taxaceae</i> family species. Extracts and individual substances in the experiment <i>in vivo, in vitro,</i> and <i>in silico</i> display a broad range of pharmacological activity: antitumor, antiproliferative, cytotoxic, antioxidant, anxiolytic, antinociceptive, antiosteoporotic, anti-inflammatory, antibacterial, antiviral, neuroprotective, hypoglycemic, etc. The information presented in this review shows that plants of the <i>Taxaceae</i> family and their individual metabolites are promising for further study.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Family Taxaceae S.F.Gray: Composition of Metabolites, Pharmacological Properties, Drugs (A Review)

  • 期刊论文

  • 发表日期：

    2025年12月15日

查看全文
  • N. E. Kolomiets,
  • A. A. Mar’in

摘要

Abstract

This review provides information on the systematics, distribution, composition of metabolites, and biological activity of plants of the Taxaceae S.F.Gray family, comprising eight genera. According to taxonomists, the family has 30–35 species, most of which are endemic to Asia. Across the globe medicine, since the 1990s, the Taxaceae family has been known for the preparations Paclitaxel®, Docetaxel®, and Synribo® with antitumor effect, produced from some species of this family. In traditional Indian (Ayurveda) medicine, Tibetan medicine, and Chinese medicine, various parts of Taxus baccata, Taxus wallichiana, Cephalotaxus hainanensis, Cephalotaxus mannii, and Torreya grandis are used. The most extensively studied are the antitumor properties and composition of metabolites of some of the 17 species of the Taxaceae family: Taxus brevifolia, Taxus baccata, Taxus cuspidata, Taxus wallichiana, Taxus yunnanensis, Torreya nucifera, Torreya grandis, Cephalotaxus wilsoniana, Cephalotaxus sinensis, Cephalotaxus oliveri, Cephalotaxus lanceolata, Cephalotaxus koreana, Cephalotaxus harringtonia, Cephalotaxus hainanensis, Cephalotaxus griffithii, Cephalotaxus fortunei, and Amentotaxus formosana. In the studied species, over 900 substances belonging to different classes of chemical compounds were identified: alkaloids, terpenoids, fatty acids, phenolic compounds (simple phenols, phenolic carboxylic acids, flavonoids, tannins), vitamins, lignans, sterols, amino acids, etc. An important marker of the family is probably taxane diterpenes, which were found in the 17 species of the Taxaceae family. According to the literature, this group of substances, as well as alkaloids, are decisive in the antitumor effect exerted by Taxaceae family species. Extracts and individual substances in the experiment in vivo, in vitro, and in silico display a broad range of pharmacological activity: antitumor, antiproliferative, cytotoxic, antioxidant, anxiolytic, antinociceptive, antiosteoporotic, anti-inflammatory, antibacterial, antiviral, neuroprotective, hypoglycemic, etc. The information presented in this review shows that plants of the Taxaceae family and their individual metabolites are promising for further study.