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Abstract <p><b>Objective:</b> A multi-component development method that does not include a catalyst has been developed for the environmentally friendly synthesis of pyranopyrazole derivatives containing a thioether bond. <b>Methods:</b> This method includes non-hazardous solvents and catalysts, conducts a basic workup, and achieves quantitative yields to eliminate contaminants. Furthermore, the antifungal and antibacterial characteristics of all the reported compounds were examined. <b>Results and Discussion:</b> Compounds (<b>Ve</b>) and (<b>Vf</b>) demonstrated superior antifungal activity compared to fluconazole against both <i>C. albicans</i> and <i>S. cerevisiae</i> at a concentration of 40 µg/mL. <b>Conclusions:</b> The findings provide evidence that these active chemicals could be a solid foundation for future research into developing novel antioxidant and antibacterial medications.</p>

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A New Green and Efficient Method for Pyranopyrazoles Synthesis in a Single Pot Using Multiple Components, In Silico Pharmacokinetics with Cytotoxic Assessments

  • 期刊论文

  • 发表日期：

    2025年2月12日

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  • N. N. Jha,
  • B. R. Thorat,
  • S. N. Mali,
  • S. A. Tawade,
  • Umang Shah,
  • R. S. Yamgar

摘要

Abstract

Objective: A multi-component development method that does not include a catalyst has been developed for the environmentally friendly synthesis of pyranopyrazole derivatives containing a thioether bond. Methods: This method includes non-hazardous solvents and catalysts, conducts a basic workup, and achieves quantitative yields to eliminate contaminants. Furthermore, the antifungal and antibacterial characteristics of all the reported compounds were examined. Results and Discussion: Compounds (Ve) and (Vf) demonstrated superior antifungal activity compared to fluconazole against both C. albicans and S. cerevisiae at a concentration of 40 µg/mL. Conclusions: The findings provide evidence that these active chemicals could be a solid foundation for future research into developing novel antioxidant and antibacterial medications.