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Abstract <p>This review aims to evaluate the mechanisms of action of current and emerging anti-TB drugs and molecules, emphasizing hydrazone functionality. Hydrazone compounds, featuring an azomethine group (R<sub>1</sub>–HN–N=CR<sub>2</sub>R<sub>3</sub>), exhibit potent anti-TB and broad-spectrum anti-infective properties. It includes the synthesis and biological testing of hydrazide-hydrazones, with a focus on their anti-TB activities reported in the literature. It highlights promising candidates for future anti-TB therapies, underscoring hydrazones’ role as a crucial pharmacophore in drug design against tuberculosis and other infectious diseases. This review summarizes pivotal findings in the development of hydrazone-based compounds, contributing to the ongoing search for effective anti-infective agents.</p>

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Hydrazide-Hydrazone Derivatives and Their Antitubercular Activity

  • 期刊论文

  • 发表日期：

    2025年2月12日

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  • B. R. Thorat,
  • S. N. Mali,
  • Umang Shah,
  • A. Garg,
  • R. Agrawal,
  • S. A. Arvindekar,
  • J. N. Cruz,
  • M. Santana de Oliveira,
  • A. B. Shaik,
  • B. V. S. Lokesh

摘要

Abstract

This review aims to evaluate the mechanisms of action of current and emerging anti-TB drugs and molecules, emphasizing hydrazone functionality. Hydrazone compounds, featuring an azomethine group (R1–HN–N=CR2R3), exhibit potent anti-TB and broad-spectrum anti-infective properties. It includes the synthesis and biological testing of hydrazide-hydrazones, with a focus on their anti-TB activities reported in the literature. It highlights promising candidates for future anti-TB therapies, underscoring hydrazones’ role as a crucial pharmacophore in drug design against tuberculosis and other infectious diseases. This review summarizes pivotal findings in the development of hydrazone-based compounds, contributing to the ongoing search for effective anti-infective agents.