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Abstract <p>Melanoma is the predominant skin cancer with the potential for metastasis. The disease has inferred an enhancing trend worldwide during recent years, needing proper therapeutic approaches. Liposomes place among the leading vesicular drug delivery platforms, permitting controlled release, targeted therapy, and hence exerting minimal off-target toxicity. They can be prepared in various sizes, entrap various hydrophilic and hydrophobic medicines, and load various lipid- and water -soluble drugs and compounds in relatively high amounts. Liposomes protect the cargo and endure within the biological structures against degradation and clearance. They are biologically inert and biodegradable and decrease the toxicity, antigenicity, or pyrogenicity of medicinal compounds. The combination therapy of liposomal delivery with chemotherapeutics and immunotherapy approaches has been promising. In this study, we provide the results of a biological activity evaluation of liposomes in melanoma cancer. This review will be useful in different disciplines, such as organic chemistry, pharmacology, medicinal chemistry, biochemistry, and oncology.</p>

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Recent Advances in Liposomes Efficacy as a Drug Delivery Platform for Melanoma Treatment

  • 期刊论文

  • 发表日期：

    2025年2月12日

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  • Elham Zarenezhad,
  • Zahra Kazeminejad,
  • Mahsa Rostami Chijan,
  • Mahmoud Osanloo,
  • Ensieh Nournia,
  • Abdolmajid Ghasemian,
  • Mahrokh Marzi

摘要

Abstract

Melanoma is the predominant skin cancer with the potential for metastasis. The disease has inferred an enhancing trend worldwide during recent years, needing proper therapeutic approaches. Liposomes place among the leading vesicular drug delivery platforms, permitting controlled release, targeted therapy, and hence exerting minimal off-target toxicity. They can be prepared in various sizes, entrap various hydrophilic and hydrophobic medicines, and load various lipid- and water -soluble drugs and compounds in relatively high amounts. Liposomes protect the cargo and endure within the biological structures against degradation and clearance. They are biologically inert and biodegradable and decrease the toxicity, antigenicity, or pyrogenicity of medicinal compounds. The combination therapy of liposomal delivery with chemotherapeutics and immunotherapy approaches has been promising. In this study, we provide the results of a biological activity evaluation of liposomes in melanoma cancer. This review will be useful in different disciplines, such as organic chemistry, pharmacology, medicinal chemistry, biochemistry, and oncology.