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Abstract <p><b>Objective:</b> To develop and synthesize new hybrid compounds incorporating hexahydro-1<i>H</i>-xanthene-1,8(2<i>H</i>)-dione and 1,2,3-triazole with potential free radical inhibitory activity. <b>Methods:</b> The structures of all synthesized compounds were confirmed by <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy, as well as by elemental analysis. A molecular docking study was conducted for the designed compounds against the 1PRX receptor. Furthermore, the antioxidant activity of all synthesized compounds was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), and nitric oxide (NO) assays. <b>Results and Discussion:</b> A direct transformation of a xanthene-based intermediate into triazole hybrids <i>via</i> a Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) reaction was developed, affording the desired products in 73–91% yields. <b>Conclusions:</b> Compound (<b>VIIh</b>) exhibited notable antioxidant potential compared to the reference standard.</p>

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Synthesis, Biological Evaluation, and Molecular Docking Studies of Hexahydro-1H-xanthene-1,8(2H)-dione and 1,2,3-Triazole Hybrids as Potent Free Radical Scavengers

  • 期刊论文

  • 发表日期：

    2025年7月28日

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  • Jaydeep N. Lalpara,
  • Bhavin B. Dhaduk,
  • G. G. Dubal,
  • Maneesh Kumar Gupta,
  • Chandan Kumar Pashavan,
  • Jayendra Kanzariya,
  • Rakesh Rola,
  • Mayur Shiyal,
  • Sanjay D. Hadiyal

摘要

Abstract

Objective: To develop and synthesize new hybrid compounds incorporating hexahydro-1H-xanthene-1,8(2H)-dione and 1,2,3-triazole with potential free radical inhibitory activity. Methods: The structures of all synthesized compounds were confirmed by 1H and 13C NMR spectroscopy, as well as by elemental analysis. A molecular docking study was conducted for the designed compounds against the 1PRX receptor. Furthermore, the antioxidant activity of all synthesized compounds was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2), and nitric oxide (NO) assays. Results and Discussion: A direct transformation of a xanthene-based intermediate into triazole hybrids via a Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) reaction was developed, affording the desired products in 73–91% yields. Conclusions: Compound (VIIh) exhibited notable antioxidant potential compared to the reference standard.