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Abstract <p>ctive: Novel 2,3-diarylsubstituted-1,3-thiazolidin-4-one derivatives (IVa–IVm) were synthesized by reacting thioglycolic acid and Schiff bases (IIIa–IIIm) in the presence of 1,4-dioxane and ZnCl<sub>2</sub> using the conventional method. <b>Methods:</b> The structures of these compounds were confirmed by FT-IR, <sup>1</sup>H NMR, and mass spectrometry. The disc diffusion method was used to screen the antimicrobial activity of the newly synthesized compounds. Gram-negative (P. aeruginosa and E. coli) and Gram-positive (B. subtilis and S. aureus) bacterial strains were selected for antibacterial activity, using ciprofloxacin as a standard drug. Simultaneously, fungal strains (C. albicans and A. niger) were tested for antifungal activity using the standard drug fluconazole. <b>Results and Discussion:</b> The results of the study suggested that the synthesized derivatives showed good antibacterial and antifungal activity against all tested organisms. <b>Conclusions:</b> Compounds substituted with –OH, –Cl, –NO<sub>2</sub>, and –OCH<sub>3</sub> groups on the aryl ring showed the maximum antibacterial and antifungal activity.</p>

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Synthesis and Antimicrobial Screening of Some Thiazolidin-4-one Derivatives

  • 期刊论文

  • 发表日期：

    2025年4月6日

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  • M. Yadav,
  • A. Kumar,
  • Y. Murti,
  • A. Jain,
  • R. Dinkar,
  • S. N. Mali

摘要

Abstract

ctive: Novel 2,3-diarylsubstituted-1,3-thiazolidin-4-one derivatives (IVa–IVm) were synthesized by reacting thioglycolic acid and Schiff bases (IIIa–IIIm) in the presence of 1,4-dioxane and ZnCl2 using the conventional method. Methods: The structures of these compounds were confirmed by FT-IR, 1H NMR, and mass spectrometry. The disc diffusion method was used to screen the antimicrobial activity of the newly synthesized compounds. Gram-negative (P. aeruginosa and E. coli) and Gram-positive (B. subtilis and S. aureus) bacterial strains were selected for antibacterial activity, using ciprofloxacin as a standard drug. Simultaneously, fungal strains (C. albicans and A. niger) were tested for antifungal activity using the standard drug fluconazole. Results and Discussion: The results of the study suggested that the synthesized derivatives showed good antibacterial and antifungal activity against all tested organisms. Conclusions: Compounds substituted with –OH, –Cl, –NO2, and –OCH3 groups on the aryl ring showed the maximum antibacterial and antifungal activity.