Synthesis, Characterization of Novel Thiazole Hydrazine Derivatives, and Inhibitory Action Against the VEGFR-2

Objective: Synthesis, characterization of novel thiazole hydrazine derivatives and inhibitory action against the VEGFR-2. Methods: The novel synthesized derivatives were appraised for their ability to inhibit the growth of cancer cells in vitro utilizing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay method. Results and Discussion: The synthesized derivatives divulge moderate to noteworthy in vitro anticancer activity towards the chosen cancer cell lines. Compounds (Va), (Vb), and (Ve) exhibited prominent anticancer activities with IC₅₀ values 10.24–15.44 µM. Conclusions: Amongst these, compound (Va), (Vb), and (Ve) showed the most potent inhibition when compared with other tested compounds. Thus, the reports obtained of the current studies divulge that the thiazole hydrazine derivatives can be developed as auspicious anticancer entities in future.