Synthesis of Morpholine Linked Indole-1,2,3-triazole Hybrids as In Vitro Tubulin Polymerization Inhibiting Agents

Objective: Synthesis of some new some new morpholine linked indole-1,2,3-triazole hybrids and evaluation of their anti-cancer activity. Methods: Cu (I) catalyzed azide-alkyne cycloaddition. MTT assay was used in anticancer activity. Autodock tools were used foe docking studies. Results and Discussion: All the sixteen compounds were screened against A549 (lung), MCF-7 (breast), and HeLa (cervical) and compared with nocodazole. In addition to this tubulin polymerization inhibition assay and docking studies were performed on some active compounds. Conclusions: Synthesized some new 1,2,3-triazole hybrids and screened them for anticancer activity, tubulin polymerization inhibition, and binding interaction with tubulin. Some of the compounds were found active.