Abstract <p>The possibility and efficiency of sorption of artificial (¹³⁷Cs), natural (²¹⁰Pb, ²¹⁰Po, ²²⁶Ra, ²²⁸Ra, ²³⁴Th), and cosmogenic (⁷Be, ³²P, ³³P) radionuclides from large volumes of seawater using various types of sorbents were evaluated. The sorption of the radionuclides studied was scaled up and optimized, and the optimal parameters of the sorption preconcentration were established. Based on the data obtained, a comprehensive method for simultaneous preconcentration of a wide range of radionuclides from seawater using the most efficient sorbents was developed and tested. By this method, diverse radionuclides can be concentrated from a single sample, which significantly simplifies the sampling procedures and field research.</p>