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“2+1B” Technetium-99m Tricarbonyl Complexes with N,N'-Bidentate Ligands and Methyl 14-Isocyano-3-methyltetradecanoate

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2024年8月1日

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  • A. E. Miroslavov,
  • P. M. Kuz’menko,
  • M. Yu. Tyupina,
  • A. P. Sakhonenkova,
  • G. V. Sidorenko,
  • A. R. Kochergina,
  • S. A. Krotov

摘要

Abstract

A novel 12-step procedure was developed for preparing methyl 14-isocyano-3-methyltetradecanoate. “2+1B” tricarbonyl complexes [99mTc(CO)3(N^N)CN(CH2)11CH(CH3)CH2COOMe]+, where N^N = 2,2'-bipyridine (bipy) or 1,10-phenanthroline (phen), were prepared by the reaction of [99mTc(CO)3(N^N)(H2O,EtOH)]+ with methyl 14-isocyano-3-methyltetradecanoate in aqueous ethanol. The formation of technetium-99m complexes was confirmed by HPLC, and the partition coefficient (n-octanol/water) of these complexes was measured.