Features of the Sorption Interaction of [³H]Hyaluronic Acid with Hydroxyapatite

[³H]Hyaluronic acid with a molecular weight of 2.37 MDa and a specific radioactivity of 35 GBq/g was obtained using the tritium thermal activation method. Tritium labeled hyaluronic acid (HA) with a molecular weight of 2.37, 0.20, and 0.10 MDa were used to study their adsorption on hydroxyapatite (HAP) in two textural modifications: aqueous suspension and powder. Differences in adsorption kinetics and adsorption isotherms were observed due to variations in the interaction between polysaccharide molecules and the sorbent forms under consideration. The adsorption isotherms of HA on HAP were proven linear. It is shown that strong HA–HAP complexes are formed, and no desorption of HA into water and 0.9% NaCl solution were detected in 2 days.