The Influence of the Sizes of Nanodiamond Aggregates in Suspensions on the Efficiency of Sorption of ⁹⁰Y and ¹⁷⁷Lu Isotopes for Further Use in Nuclear Medicine

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发表日期：

2024年4月1日

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A. G. Kazakov,
J. S. Babenya,
T. Y. Ekatova,
S. E. Vinokurov,
E. Y. Khvorostinin,
I. A. Ushakov,
V. V. Zukau,
E. S. Stasyuk,
E. A. Nesterov,
V. L. Sadkin,
A. S. Rogov,
B. F. Myasoedov

摘要

Abstract

Nanodiamonds (NDs) are promising carriers of radionuclides in radiopharmaceuticals for the use in nuclear medicine. In this work, we investigated the influence of the properties of NDs suspensions, including the sizes of their aggregates, in aqueous solutions with different pH on their binding of medical isotopes ⁹⁰Y and ¹⁷⁷Lu and determination of conditions for fabricating promising conjugates for further in vivo studies. It was shown that sorption is influenced by the composition of the solution, which determines the properties of the NDs surface, while the forms of cations of the studied nuclides in the solution do not affect the sorption value.

The Influence of the Sizes of Nanodiamond Aggregates in Suspensions on the Efficiency of Sorption of 90Y and 177Lu Isotopes for Further Use in Nuclear Medicine

摘要

The Influence of the Sizes of Nanodiamond Aggregates in Suspensions on the Efficiency of Sorption of ⁹⁰Y and ¹⁷⁷Lu Isotopes for Further Use in Nuclear Medicine