Nanodiamonds as Lutetium-177 Carriers for Nuclear Medicine

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2024年4月1日

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A. G. Kazakov,
J. S. Babenya,
T. Y. Ekatova,
S. E. Vinokurov,
E. Y. Khvorostinin,
I. A. Ushakov,
V. V. Zukau,
E. S. Stasyuk,
E. A. Nesterov,
V. L. Sadkin,
A. S. Rogov,
B. F. Myasoedov

摘要

Abstract

The work investigated the sorption of no-carrier-added ¹⁷⁷Lu isolated from neutron-irradiated ¹⁷⁶Yb₂O₃, and carrier-added ¹⁷⁷Lu obtained by irradiation of ^natLu₂O₃, by commercial and oxidized nanodiamonds (NDs) of various grades from aqueous solutions to identify among them a promising carrier for further research in the field of nuclear medicine. A promising sorbent was found: oxidized NDs of the STP grade (ox-STP); conditions for the fast sorption of lutetium with it in an amount equivalent to 1.2 GBq of no-carrier-added ¹⁷⁷Lu were determined, which corresponds to the activity used in therapy.