Modeling a DNA-Origami Nanoplatform for Super-Resolution Luminescent Imaging

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发表日期：

2026年6月8日

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U. A. Khokhryakova,
M. E. Stepanov,
A. I. Arzhanov,
T. V. Egorova,
A. V. Naumov

摘要

Abstract

The DNA origami method enables the creation of nanostructures with nanometer-scale precision, surpassing the diffraction limit of light, making it an effective tool for super-resolution microscopy. This work examines the application of DNA origami in nanoscopy and proposes a model nanostructure with positions for anchoring fluorescent emitters. It is shown that the structure can be used as a calibration nanoruler for STED, MINFLUX, STORM, PALM, cryogenic ZPL nanoscopy, and luminescent imaging based on quantum dots, as well as a platform for DNA-PAINT. The possibility of adapting the design to various super-resolution methods with minimal modifications is demonstrated.