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Abstract <p>The effect of the concentration of lithium introduced into hydroxyapatites is investigated over the broad range of 1 to 20 mol %. It is shown that raising the content of Li<sup>+</sup> ions results in a corresponding increase in the relative permittivity. The incorporation of lithium does not induce acute cytotoxicity. Rather, it enhances the proliferation of the MG-63 cell line during in vitro experiments, with observed positive dynamics over periods of up to 7 days.</p>

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Electrophysical and Biological Properties of Lithium-Doped Hydroxyapatite In Vitro

  • 期刊论文

  • 发表日期：

    2025年10月28日

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  • M. A. Goldberg,
  • M. R. Gafurov,
  • I. V. Lounev,
  • A. S. Fomin,
  • S. V. Smirnov,
  • T. O. Obolkina,
  • O. S. Antonova,
  • S. A. Akhmedova,
  • V. A. Kirsanova,
  • I. K. Sviridova,
  • N. S. Sergeeva,
  • A. V. Leonov,
  • S. M. Barinov,
  • V. S. Komlev

摘要

Abstract

The effect of the concentration of lithium introduced into hydroxyapatites is investigated over the broad range of 1 to 20 mol %. It is shown that raising the content of Li+ ions results in a corresponding increase in the relative permittivity. The incorporation of lithium does not induce acute cytotoxicity. Rather, it enhances the proliferation of the MG-63 cell line during in vitro experiments, with observed positive dynamics over periods of up to 7 days.