Generation of Two iPSC Lines (FAMRCi011-A and FAMRCi011-B) from a Patient with Dilated Cardiomyopathy and Ventricular Tachycardia Carrying the Genetic Variant FLNC p.Arg1267Gln
摘要
Human iPSC lines (FAMRCi011-A and FAMRCi011-B) were generated from a patient with dilated cardiomyopathy and ventricular tachycardia carrying the genetic variant FLNC p.Arg1267Gln. Peripheral blood mononuclear cells were reprogrammed using non-integrative Sendai viruses. Established iPSC lines were characterized according to common guidelines: demonstration of the positive expression of markers specific to pluripotent cells, the absence of major karyotype abnormalities, and the ability to differentiate toward three germ layers in vitro. The reported iPSC lines could be a useful tool for in vitro modeling of progressive cardiac conduction disease associated with mutations in desmosomal genes.